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S a f e t y D a t a S h e e t

According to Regulation (EC) 1907/2006

1147 Acetic Anhydride

Identification of the substance/preparation and of the company or firm

1.1 Identification of the substance or preparation

Name:

Acetic Anhydride

Synonym:

REACH Registration Number: 01-2119486470-36-XXXX

1.2 Use of the substance/preparation:

For laboratory utilisation, analysis, research and fine chemistry.

1.3 Identification of the company or firm:

PANREAC QUIMICA S.L.U.

C/Garraf 2

Polígono Pla de la Bruguera

E-08211 Castellar del Vallès

(Barcelona) Spain

Tel. (+34) 937 489 400

e-mail: product.safety@panreac.com

1.4 Emergency telephone:

Single telephone number for emergency calls: 112 (EU)

Tel.: (+34) 937 489 499

Identification of dangers

Classification of the substance or the mixture.

Classification Regulation (CE) nº 1272/2008.

Flam. Liq. 3

Acute Tox. 4

Acute Tox. 4

Skin Corr. 1B

Hazard Pictograms

Signal word

Danger

Hazard statements

H226 Flammable liquid and vapour.

H332 Harmful if inhaled.

H302 Harmful if swallowed.

H314 Causes severe skin burns and eye damage.

Precautionary statements

P210 Keep away from heat/sparks/open flames/hot surfaces. No smoking.

P233 Keep container tightly closed.

P240 Ground/bond container and receiving equipment.

P241 Use explosion-proof electrical/ventilating/lighting/.../ equipment.

P242 Use only non-sparking tools.

P243 Take precautionary measures against static discharge.

Classification (67/548/CEE or 1999/45/CE).

C Corrosive

R34

R20/22

R10

For the full text of the R-phrases mentioned in this section, see section 16.

Component Composition/Information

Name: Acetic Anhydride

Formula: (CH3CO)2O M.= 102,09 CAS [108-24-7]

EC number (EINECS): 203-564-8

EC index number: 607-008-00-9

REACH Registration Number: 01-2119486470-36-XXXX

First aid

4.1 General indications:

Never provide drink or induce vomiting in the event of loss of consciousness.

4.2 Inhaling:

Take the person out into the fresh air. In the event sickness persists, seek medical assistance.

4.3 Contact with the skin:

Wash with plenty of water. Remove contaminated clothing.

4.4 Eyes:

Wash with plenty of water (for at least 15 minutes), keeping eyelids open. Seek immediate medical assistance.

4.5 Swallowing:

Drink large amounts of water. Avoid vomiting (there is a risk of perforation). Seek immediate medical assistance. Do not neutralize.

Fire-fighting means

5.1 Suitable fire-extinguishing means:

Dry powder.

5.2 Fire-fighting means which must NOT be used:

Water. Foam.

5.3 Special risks:

Flammable. Keep away from sources of ignition. The fumes are heavier than air, so they may spread at floor level. May form explosive mixtures with the air. In the event of fire, toxic fumes may form. Risk of inflammation due to accumulation of electrostatic charges.

5.4 Protective equipment:

Suitable clothing and footwear.

Measures to be taken in the event of accidental spillage

6.1 Individual precautions:

Do not inhale the fumes.

6.2 Precautions for care of the environment:

Avoid pollution of the soil, water supplies and drains.

6.3 Methods for collection/cleaning:

Collect up with absorbent materials (Panreac General Absorbent, Kieselguhr, etc.) or, if none available, dry sand or earth, and deposit in waste containers for subsequent elimination in accordance with current legislation. Clean any remains with plenty of water. Neutralize with diluted sodium hydroxide.

Handling and storage

7.1 Handling:

No special indications.

7.2 Storage:

Well sealed containers.Dry atmosphere.In well ventilated premises.Away from sources of ignition and heat.Room temperature.

Staff exposure/protection controls

8.1 Technical protective measures:

No special indications.

8.2 Exposure limit control:

VLA-ED: 5 ppm - 21 mg/m3

8.3 Respiratory protection:

In the event of fumes forming/aerosols, use suitable respiratory protection. Filter A.

8.4 Hand protection:

Use suitable gloves

8.5 Eye protection:

Use suitable goggles.

8.6 Individual hygiene measures:

Remove contaminated clothing. Use suitable work clothing. Wash hands and face before breaks and when the job is done.

8.7 Environmental exposure controls:

Fulfill the commitments under local environmental protection legislation.

Physical and chemical properties

Appearance: liquid

Colour: Colourless

Granulometry: N/A

Odour: Piquant.

pH: 3 ((10 g/l sol.))

Melting point/freezing point: -73 °C

Initial boiling point and boiling range: 136 - 142 °C

Flash point: 54 °C

Flammability (solid, gas):

N/A

Upper/lower flammability or explosive limits: 10,2 %(V) / 2 %(V)

Vapour pressure: 5 hPa (20 °C)

Vapour density: N/A

Relative density: (20/4) 1,082

Solubility: in Reacts violently with water and ethanol. Miscible with ether, chloroform or benzene

Partition coefficient: n-octanol/water:

N/A

Auto-ignition temperature: 389 °C

Decomposition temperature: N/A

Viscosity: N/A

Stability and reactivity

10.1 Conditions which should be avoided:

The product is chemically stable under standar ambient conditions (room temperature).

10.2 Matter which should be avoided:

Acids. Water. Alcohols. Ammonia. Oxidant agents (amongst others: perchloric acid, perchlorates, halogenates, CrO3, halogen oxides, nitric acid, nitrogen oxides, non-metal oxides, chromo-sulphuric acid). Alkaline hydroxides.

10.3 Hazardous decomposition products:

No specific data.

10.4 Complementary information:

The gases/fumes can form explosive mixtures with the air.

Toxicological information

  • Acute toxicity:

LD50 oral rat : 1.780 mg/kg

LD50 skn rbt : 4.000 mg/kg

LC50 inh rat : 1000 ppm 4h

  • Dangerous effects for health:

If fumes inhaled: Irritations to the respiratory tracts. Very corrosive substance. Can cause bronchopneumonia oedemas in the respiratory tract Upon contact with the skin: burns Through contact with the eyes: burns sight disorders blindness (irreversible injury of the optic nerve) Burns in the mucosae. If swallowed: Burns in the oesophagus and stomach. spasms vomiting breathing difficulties Risk of perforation in the oesophagus and stomach. Risk of aspiration upon vomiting. The following cannot be ruled out: shock cardiovascular failure acidosis kidney problems alterations of the circulation

Environmental information

12.1 Toxicity:

12.1.1 - EC50 test (mg/l):

Fish (Leuciscus Idus) 410 mg/l

Classification:

Highly toxic

Fish (L. Macrochirus) 75 mg/l

Classification:

Extr. toxic

Crustaceans (Daphnia magna) 47 mg/l

Classification:

Extr. toxic

Bacteria (Photobacterium phosphoreum) 11 mg/l

Classification:

Extr. toxic

12.1.2. - Receptor medium:

Risk for the water environment

High

Risk for the land environment

Medium

12.1.3. - Observations:

Highly toxic in water environments. Affects fish, micro-crustaceans and bacteria due to pH deviation.

Acute ecotoxicity in line with the dumping concentration.

12.2 Persistence and Degradability :

12.2.1 - Test:

12.2.2. - Biotic degradation classification:

BOD5 0,88 g/g

BOD5/COD

Biodegradability

12.2.3. - Abiotic degradation depending on pH:

12.2.4. - Observations:

Biodegradable product.

12.3 Bioaccumulative potential:

12.3.1. - Test:

12.3.2. - Bioaccumulation:

Risk

12.3.3. - Observations:

Non-bioaccumulable product.

12.4 Mobility in soil :

Repartition: log P(oct)= -0,31

12.5 Assessment PBT and MPMB :

Data not available.

12.6 Other possible effects on the environment:

Ecotoxic effects due to the pH variation.

Considerations regarding elimination

13.1 Substance or preparation:

In the European Union, there are no homogeneous standards established for elimination of chemical waste, which is waste of a special nature, and treatment and elimination of same is subject to the domestic legislation in each country.

In view of this, in each case, you should contact the competent authority or those companies legally authorized for elimination of waste.

2001/573/EC: Council Decision of 23 July 2001 amending Commission Decision 2000/532/EC as regards the list of wastes.Council Directive 91/156/EEC of 18 March 1991 amending Directive 75/442/EEC on waste.

.

13.2 Contaminated containers:

Contaminated containers and packaging of dangerous substances or preparations must be treated in the same manner as the actual products contained in them.

European Parliament and Council Directive 94/62/EC of 20 December 1994 on packaging and packaging waste.

.

Information concerning transport

Overland (ADR):

Technical name: ACETIC ANHYDRIDE

UN 1715 Class: 8 3 Packaging group: II (D/E)

By sea (IMDG):

Technical name: ACETIC ANHYDRIDE

UN 1715 Class: 8 3 Packaging group: II

By air (ICAI-IATA):

Technical name: Acetic anhydride

UN 1715 Class: 8 3 Packaging group: II

Packaging instructions: CAO 855 PAX 851

Regulatory information

The substance is subject to Regulation (EC) No 273/2004 of the European Parliament and of the Council, of 11 February 2004 on drug precursors, Council Regulation (EC) No 111/2005 of 22 December 2004 laying down rules for the monitoring of trade between the Community and third countries in drug precursors, Commission Regulation (EC) No 1277/2005 of 27 July 2005 laying down implementing rules for Regulation (EC) No 273/2004 of the European Parliament and of the Council on drug precursors and for Council Regulation (EC) No 111/2005 laying down rules for the monitoring of trade between the Community and third countries in drug precursors.

Other information

Other precautionary statements

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P264 Wash...thoroughly after handling.

P270 Do no eat, drink or smoke when using this product.

P271 Use only outdoors or in a well-ventilated area.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312 IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.

P301+P330+P331 IF SWALLOWED: rinse mouth. Do NOT induce vomiting.

P303+P361+P353 IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.

P304+P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P310 Immediately call a POISON CENTER or doctor/physician.

P312 Call a POISON CENTER or doctor/physician if you feel unwell.

P321 Specific treatment (see on this label).

P330 Rinse mouth.

P338 Remove contact lenses, if present and easy to do. Continue rinsing.

P363 Wash contaminated clothing before reuse.

P370+P378 In case of fire: Use for extinction.

P403+P235 Store in a well-ventilated place. Keep cool.

P405 Store locked up.

P501 Dispose of contents/container according to Directive 94/62/CE or 2008/98/CE.

Labelling (65/548/CEE or 1999/45/CE)

R-phrase(s):

R34 Causes burns.

R20/22 Harmful by inhalation and if swallowed.

R10 Flammable.

S-phrase(s):

S45 In case of accident or if you feel unwell, seek medical advice immediately (show the lable where possible).

S36/37/39 Wear suitable protective clothing, gloves and eye/face protection.

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

Review number and date: 4 15.09.2011

Date published: 15.09.2011

In respect of the previous review, changes have been made to the following sections: 15

The information included in this Safety Data Sheet is based on our most up-to-date knowledge, and is solely intended to inform regarding aspects of safety; the properties and characteristics indicated herein are not guaranteed.

S a f e t y D a t a S h e e t

в соответствии с Regulation (EC) 1907/2006

1147 Уксусн. Ангидрид

Определение вещества/preparation и the company или firm

1.1 Определение вещества или preparation

Название:

Уксусн. Ангидрид

Synonym:

REACH Registration Number: 01-2119486470-36-XXXX

1.2 Use вещества/preparation:

Для общелабораторного использования, анализов, исследований и тонкой химии.

1.3 Сведения о компании или фирме:

PANREAC QUIMICA S.L.U.

C/Garraf 2

Polígono Pla de la Bruguera

E-08211 Castellar del Vallès

(Barcelona) Spain

Tel. (+34) 937 489 400

e-mail: product.safety@panreac.com

1.4 Emergency telephone:

Single telephone number for emergency calls: 112 (EU)

Tel.: (+34) 937 489 499

Виды опасного воздействия

Классификация вещества или the mixture.

Классификация Regulation (CE) nº 1272/2008.

Flam. Liq. 3

Acute Tox. 4

Acute Tox. 4

Skin Corr. 1B

Hazard Pictograms

Signal word

Danger

Hazard statements

H226 Воспламеняем жидкость и vapour.

H332 Вредный if inhaled.

H302 Вредный При попадании внутрь.

H314 Causes severe skin ожоги и eye damage.

Precautionary statements

P210 Keep away from heat/sparks/open flames/hot surfaces. Не курить.

P233 Keep container tightly closed.

P240 Ground/bond container и receiving equipment.

P241 Use explosion-proof electrical/ventilating/lighting/.../ equipment.

P242 Use only non-sparking tools.

P243 Take precautionary measures against static discharge.

Классификация (67/548/CEE или 1999/45/CE).

C Коррозионное Вещество

R34

R20/22

R10

For the full text the R-выражения mentioned в this section, see section 16.

Сведения о компонентах и состав

Название: Уксусн. Ангидрид

Формула: (CH3CO)2O M.= 102,09 CAS [108-24-7]

Номер ЕС (EINECS): 203-564-8

ЕС индекс: 607-008-00-9

REACH Registration Number: 01-2119486470-36-XXXX

Первая помощь

4.1 Общие указания:

Не давать пить и не вызывать рвоту при потере сознания.

4.2 Вдыхание:

Переместить пострадавшего на свежий воздух. При ухудшении самочувствия, Обратиться за медицинской помощью.

4.3 Контакт с кожей:

Промыть большим количеством воды. Избавиться от загрязненной одежды.

4.4 Глаза:

Промыть большим количеством воды (не менее 15 minutes), Веки постоянно держать открытыми. Обратиться немедленно за медицинской помощью.

4.5 Попадание Внутрь:

Выпить большое количество воды. Avoid рвота (there is a риск perforation). Обратиться немедленно за медицинской помощью. Do not neutralize.

Меры и средства обеспечения пожаро- и взрывобезопасности

5.1 Пригодные средства пожаротушения:

Песок.

5.2 Меры и средства обеспечения пожаро- и взрывобезопасности which must NOT be used:

Вода. Пена.

5.3 Особая опасность:

Воспламеняем. Держать на расстоянии от источников возгорания. The fumes are heavier than air, so they may spreaD при floor level. Могут образовывать взрывоопасные соединения с воздухом. В случае возгорания могут образовываться токсичные пары. Существует риск воспламенения из-за образования электростатических разрядов.

5.4 Средства индивидуальной защиты:

Специальная одежда и обувь.

Меры по предотвращению и ликвидации чрезвычайных ситуаций

6.1 Индивидуальные меры предосторожности:

Не вдыхать пары.

6.2 Меры по защите окружающей среды:

Избегайте загрязнения почвы, систем водоснабжения и дренажа.

6.3 Методы нейтрализации и очистки:

Собирать с помощью абсорбирующего материала ( Panreac абсорбент общего назначения, Kieselguhr, etc), если абсорбент не доступен использовать сухой песок или землю и поместить в контейнеры для последующей утилизации в соответствии с законодательством.. Смыть остатки большим количеством воды. Neutralize с diluted Натрия гидроксид.

Правила обращения и хранения

7.1 Обращение:

Специальные указания отсутствуют.

7.2 Хранение:

В запечатанных контейнерах.Сухая атмосфера.В хорошо проветриваемом помещении.Вдали от источников возгорания и тепла.Room temperature.

Требования по охране труда и меры по обеспечению безопасности персонала

8.1 Технические меры защиты:

Специальные указания отсутствуют.

8.2 Контроль предельно допустимого уровня воздействия:

VLA-ED: 5 ppm - 21 мг/м3

8.3 Защита органов дыхания:

В the event fumes forming/aerosols, use suitable Защита органов дыхания. Фильтр A.

8.4 Защита рук:

Использовать защитные перчатки

8.5 Защита глаз:

Использовать защитные очки.

8.6 Индивидуальные средства гигиены:

Избавиться от загрязненной одежды. Использовать специальную одежду. Мыть руки и лицо перед перерывами и после окончания работы.

8.7 Контроль воздействия на окружающую среду:

Выполнять предписания по охране окружающей среды в соответствии с местным законодательством.

Физико-химические свойства

Внешний Вид: жидкость

Цвета: Бесцветная

Granulometry: N/A

Запах: Piquant.

pH: 3 ((10 г/л sol.))

точка плавления/Температура замерзания: -73 °C

Initial Точка кипения и Интервал температур кипения: 136 - 142 °C

Точка воспламенения: 54 °C

Flammability (solid, gas):

N/A

Верхний/нижний flammability или explosive показатели: 10,2 %(V) / 2 %(V)

Давление пара: 5 hPa (20 °C)

Vapour плотность: N/A

Relative плотность: (20/4) 1,082

Растворимость: в Reacts violently с водой и этанол. Смешивается с эфир, хлороформ или бензол

Partition coefficient: n-октанол/вода:

N/A

Auto-ignition temperature: 389 °C

Decomposition temperature: N/A

Вязк.: N/A

Стабильность и реакционноспособность

10.1 Условия, которых следует избегать:

The product is chemically stable under standar ambient conditions (room temperature).

10.2 Вещества, которых следует избегать:

Кислоты. Вода. Спирт.. Аммиак. Окислители (: перхлорная кислота, перхлораты, галогены, CrO3, оксиды галогенов, Азотная кислота, оксиды азота, оксиды не металлов, раствор хромового ангидрида в серной кислоте). Щелочных hydroxides.

10.3 Опасные продукты разложения:

No specific data.

10.4 Общая информация:

The gases/fumes can form explosive mixtures с the air.

Токсикологическая информация

  • Высокая токсичность:

LD50 oral rat : 1.780 мг/кг

LD50 skn rbt : 4.000 мг/кг

LC50 inh rat : 1000 ppm 4h

  • Опасное воздействие на здоровье:

If fumes inhaled: Irritations до the respiratory tracts. Very коррозионное вещество соединен.. Can cause bronchopneumonia oedemas в the respiratory tract Upon Контакт с кожей: ожоги Контакт с глазами: ожоги sight disorders blindness (irreversible injury the optic nerve) Ожоги в the mucosae. При попадании внутрь: Ожоги в the oesophagus и stomach. spasms рвота затруднение дыхания Риск perforation в the oesophagus и stomach. Риск aspiration upon рвота. The following cannot be ruled out: shock cardiovascular failure acidosis kidney problems alterations the circulation

Информация по окружающей среде

12.1 Toxicity:

12.1.1 - EC50 тест (mg/l):

Рыбы (Leuciscus Idus) 410 mg/l

Классификация:

Highly токсично

Рыбы (L. Macrochirus) 75 mg/l

Классификация:

Extr. токсично

Crustaceans (Daphnia magna) 47 mg/l

Классификация:

Extr. токсично

Бактерии (Photobacterium phosphoreum) 11 mg/l

Классификация:

Extr. токсично

12.1.2. - Воздействие на окружающую среду:

Риск для водной среды

Высокий

Риск для земли

Средний

12.1.3. - Наблюдения:

Highly токсично в воде environments. Affects рыбы, micro-crustaceans и бактерии due до pH deviation.

Acute экотоксичность в line с the dumping концентрация.

12.2 Persistence и Период Распада :

12.2.1 - Тест:

12.2.2. - Классификация биотического периода распада:

BOD5 0,88 g/g

BOD5/COD

Биоразложение

12.2.3. - Абиотический период распада зависит от рН:

12.2.4. - Наблюдения:

Biodegradable product.

12.3 Bioaccumulative potential:

12.3.1. - Тест:

12.3.2. - Биоаккумуляция:

Риск

12.3.3. - Наблюдения:

Non-bioaccumulable product.

12.4 Мобильность в soil :

Repartition: log P(oct)= -0,31

12.5 Assessment PBT и MPMB :

Нет данных.

12.6 Другие возможные воздействия на окружающую среду:

Ecotoxic effects due до the pH variation.

Правила утилизации

13.1 Вещество или препарат:

В the Европейск. Union, there are no homogeneous standards established for elimination chemical waste, which is waste a special nature, и treatment и elimination same is subject до the domestic legislation в each country.

В view this, в each case, you should contact the competent authority или those companies legally authorized for elimination waste.

.

13.2 Загрязненные контейнеры:

Загрязненные контейнеры и packaging dangerous соединения или preparations must be treated в the same manner как the actual products contained в them.

.

Информация относительно транспорта

Автотранспорт (ADR):

Техническое название: ACETIC ANHYDRIDE

UN 1715 Класс: 8 3 Группа: II (D/E)

Морской транспорт (IMDG):

Техническое название: ACETIC ANHYDRIDE

UN 1715 Класс: 8 3 Группа: II

Авиа транспорт (ICAI-IATA):

Техническое название: Уксусн. ангидрид

UN 1715 Класс: 8 3 Группа: II

Инструкция по упаковке: CAO 855 PAX 851

Regulatory information

The соединен. is subject до Regulation (EC) No 273/2004 the Европейск. Parliament и the Council, 11 February 2004 on drug precursors, Council Regulation (EC) No 111/2005 22 December 2004 laying down rules for the monitoring trade between the Community и third countries в drug precursors, Commission Regulation (EC) No 1277/2005 27 July 2005 laying down implementing rules for Regulation (EC) No 273/2004 the Европейск. Parliament и the Council on drug precursors и for Council Regulation (EC) No 111/2005 laying down rules for the monitoring trade between the Community и third countries в drug precursors.

Дополнительная информация

Др. precautionary statements

P260 Не вдыхать пыль/fume/gas/mist/vapours/spray.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P264 Wash...thoroughly после обращение.

P270 Do no eat, drink или smoke when using this product.

P271 Use only outdoors или в a well-ventilated area.

P280 Wear protective gloves/protective clothing/Защита глаз/face protection.

P301+P312 При попадании внутрь: Call a POISON CENTER или doctor/physician if you feel unwell.

P301+P330+P331 При попадании внутрь: rinse mouth. Do NOT Вызвать рвоту.

P303+P361+P353 IF ON SKIN (или hair): Remove/Take off immediately all contaminated clothing. Rinse skin с водой/shower.

P304+P340 IF INHALED: Remove victim до fresh air и keep при rest в a position comfortable for breathing.

P305+P351+P338 IF IN EYES: Rinse cautiously с водой for several minutes. Remove contact lenses, if present и easy до do. Continue rinsing.

P310 Immediately call a POISON CENTER или doctor/physician.

P312 Call a POISON CENTER или doctor/physician if you feel unwell.

P321 Specific treatment (see on this label).

P330 Rinse mouth.

P338 Remove contact lenses, if present и easy до do. Continue rinsing.

P363 Wash contaminated clothing before reuse.

P370+P378 В case fire: Use for extinction.

P403+P235 Store в a well-ventilated place. Keep cool.

P405 Store locked up.

P501 Выбросить contents/container в соответствии с Directive 94/62/CE или 2008/98/CE.

Labelling (65/548/CEE или 1999/45/CE)

R-phrase(s):

R34 Может вызвать ожоги.

R20/22 Вреден при вдыхании и При попадании внутрь.

R10 Воспламеняем.

S-phrase(s):

S45 При ухудшении самочувствия обратиться за медицинской помощью (show the lable where possible).

S36/37/39 Wear suitable protective clothing, gloves и eye/face protection.

S26 При контакте с глазами, немедленно промыть большим количеством воды и обратиться за медицинской помощью.

Номер рецензии и дата: 4 15.09.2011

Date published: 15.09.2011

Относительно предыдущего обзора изменения были произведены в следующих разделах: 15

Информация, включенная в этот сертификат безопасности, базируется на современных данных и соответствует аспектам безопасности.




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